Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse
نویسندگان
چکیده
منابع مشابه
Prepulse-elicited startle in prepulse inhibition.
BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...
متن کاملHabituation and prepulse inhibition of acoustic startle in rodents.
The acoustic startle response is a protective response, elicited by a sudden and intense acoustic stimulus. Facial and skeletal muscles are activated within a few milliseconds, leading to a whole body flinch in rodents(1). Although startle responses are reflexive responses that can be reliably elicited, they are not stereotypic. They can be modulated by emotions such as fear (fear potentiated s...
متن کاملHeritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.
Prepulse inhibition (PPI) is an acoustic startle paradigm that has been used as an operational measure of sensorimotor gating. Many patients with schizophrenia have impaired PPI, and several lines of evidence suggest that PPI may represent a heritable endophenotype in this disease. We examined startle magnitude and latencies in 40 schizophrenia patients, 58 first-degree relatives of these patie...
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this approach, we have recently identified the histamine HI-receptor as a likely proximal molecular target for atypical antipsychtoic drug-induced weight gain (Kroeze et al, Neuropsychopharmacol, in press) and are currently using datamining technologies to discover sites responsible for other actions of atypical antipsychotic drugs. We have also recently discovered that the kappa opioid recepto...
متن کاملThe effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice.
The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-) mice and in age-matched PV+/+ mice as controls. Hearing thresholds as determined from recordings of auditory brainstem responses were found to...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2017
ISSN: 2158-3188
DOI: 10.1038/tp.2017.85